The UNT Transdisciplinary Conference on Ancestral Genomics will conduct panel discussions, focused on initiatives that move us beyond the current one-size-fits-all medical paradigm, which disadvantages underrepresented populations. Workshops led by National Institutes of Health scientists will also support new collaborations. So what is “ancestral genomics”? Medical researchers sometimes lack ready access to certain vital clues relating to the unique ecological environments to which a “genetic niche population” is genomically adapted. The potential for identifying disease-causative Single Nucleotide Polymorphisms (SNPs) in non-Europeans is therefore reduced. This working Conference intends to respond to such needs.