SINS 2019 SINGAPORE’S INTERNATIONAL NEUROSCIENCE SUMMIT 2019

Singapore, Singapore
25 - 26 July 2019
61 days until the conference begins

Important Dates

Early Bird Deadline
20th April 2019
Final Abstract / Full Paper Deadline
20th July 2019
Abstract Submission Deadline
25th July 2019
Abstract Acceptance Notification
26th July 2019

About SINS 2019

INGAPORE’S INTERNATIONAL NEUROSCIENCE SUMMIT Theme: “Advanced strategies to strike out Alzheimer’s and Psychiatry disorder” Singapore | JULY 25-26, 2019

Topics

Neuoscience, Neuropsychiatry & rehabilitation, Neuro pharmacology, Neurological disorders & stroke, Neurodegenerative disorders, Neurosurgery

Call for Papers

 

The below details are required:

  • Please mention the conference Session/Topics you are interested to :
  • If this abstract is to be submitted for a Symposium or workshop of the conference, please mention it :

Challenges on Protein Bioencapsulation in Transparent Nanoporous Sol-Gel Glasses and their Applications

N. Surname,1,2,* B. Someone,1,2

1 University Name, Department of Nanobiotechnology, San Diego, USA

2 State University of Campinas, UNICAMP, (Hemocentro), Sao Paulo, Brazil

Abstract:

Transparent organic-inorganic nanoporous silica glasses obtained via the sol-gel method constitute the ideal support for protein bio-encapsulation and the study of the different factors influencing the protein folding process in a crowded environment. Due to the facile silica surface modifications with the choice of Si-substituted organic groups, organically modified “wet-aged” based silica glasses can be used as host materials to mimic the crowded environment of the proteins and cells that can be found in the cytoplasm for instance. The transparent media allows spectroscopic studies such as the use of circular dischroism spectroscopy. We report the influence of different parameters (macromolecular crowding, porosity, hydrophobicity, surface hydration) on the protein conformation based on the design and the characterization of nanoporous silica-based materials bearing different functional groups favoring the protein folding (Figure 1). The enhancement of the protein folding owing the physical properties and microstructure of the host matrix induced by the nature of the functional groups and the siloxane network play a major role on the protein biological activity and therefore to the  development efficient bionanodevices such as biocatalysts, sensors, drug delivery systems or implanted devices. In addition, we will introduce new challenges of using this type of host matrices in microbiology. This study will also permit us to discuss a new surfactant-free micropatterming process on the porous glass surface that we have enlightened with potential optical applications.

Keywords: protein folding, nanoporous sol-gel glasses, silica-based biomaterials, circular dichroism spectroscopy, surface hydration, crowding effects, micropatterning, biomedical applications.

Figure 1: Figure illustrating the fundamental question that we are tempting to solve experimentally: what is the importance of silica surface modification nanoporous silica-based sol-gel glasses prepared from functionalized organosilane precursors on the parameters affecting the conformation, biological activity and functionality of encapsulated biomolecules.

References:

  • Bouchloukh, W., Jouenne, B. (2012) Characterization of biofilms formation in urinary catheters, Amer. J. Infect. Control., In Press.
  • Montoneri, F., Montoneri, E., Boffa, V., Sharts, O. (2011), Protein helical structure enhancement in fluorinated-phosphonate nanoporous silica glasses characterized by circular dichroism spectroscopy, Int. J. Nanotech., 8, 471-491.

Keep Up to Date with PaperCrowd

Sign up and follow your favorite conferences.